This editorial and study point out that:
- Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in both children and adults
- It is likely to become a serious public health problem worldwide
- It is closely associated with obesity and insulin resistance
- It includes a spectrum of diseases from simple fatty liver (steatosis) to fibrosis and cirrhosis
- This study shows it can take only 10-20 years for the disease to progress from its first signs to irreversible end-stage disease
- There is no effective drug treatment - early diagnosis and lifestyle changes are key to stop disease progression
- Disease markers need to be developed to identify those most at risk.
Source: Gut 2009;58:1442
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