PPI 之缺點

What are the risks of long-term use of proton-pump inhibitors?

Potential risks of long-term use of proton-pump inhibitors include secondary hypergastrinemia, malabsorption, and hypochlorhydria. These risks are mainly theoretical, but large, population-based, epidemiologic studies have suggested that long-term use of proton-pump inhibitors was associated with an increased risk of hip fracture by a factor of 1.4 in subjects over 50 years (presumably attributable to calcium malabsorption), an increase in the risk of infectious gastroenteritis by a factor of 1.5, and a doubling of the risk of Clostridium difficile colitis.