年過五十歲的女性,約半數有骨質疏鬆症狀,但臨床調查發現,骨鬆患者服藥的持續性很不理想,不管是每日或每月劑型,超過五成患者會在治療一年左右即中斷用藥。醫界已就此現象研發出一年打一針的新藥,除了使用方便,實驗也證明該藥療效廣泛,可使髖骨骨折手術後的致死風險降低約三成。
新光醫院骨科主任魏志定昨說,此新藥名為「骨力強」,對患者最明顯好處為治療便利性高,只要躺或坐在病床上十五分鐘,以點滴注射,即可完成一年份用藥,但目前健保並未給付,每次自費價約兩萬五千元。
記者邱俊吉 /蘋果日報A11版
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Aclasta
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Generic Name: zoledronic acid
Brand names: Zometa, Zometa Concentrate, Aclasta, Reclast
Important information about Aclasta
通過FDA的新藥Aclasta,是目前最長效的治療骨質疏鬆症的藥,從FDA公佈的研究資料來看,新藥用於曾髖部骨折的病人身上,可降低死亡率28%,但副作用為心房顫動,發燒,肌肉,骨骼或關節疼痛,類似流感症狀以及頭痛等.
Do not receive Aclasta without telling your doctor if you have had an allergic reaction to zoledronic acid or similar medicine such as alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel), or tiludronate (Skelid). Do not use Aclasta without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.
Your doctor may recommend you have a dental exam for preventive tooth and gum care before you start your treatment with Aclasta. This is especially important if you have cancer, if you are undergoing chemotherapy or using steroids, or if you have poor dental health.
Some people using medicines similar to Aclasta have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and pre-existing dental problems.
Avoid having any type of dental surgery while you are being treated with Aclasta. It may take longer than normal for you to recover.
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http://www.drugs.com/aclasta.html
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