Hydrochlorothiazide and gout

Q: Hydrochlorothiazide can increase the risk for what problem in the joints?

A: Hydrochlorothiazide may cause hyperuricemia and, thus, over time, can increase the risk of gouty arthritis in susceptible patients.

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Teaching topics from the New England Journal of Medicine - Vol. 358, No. 23, June 5, 2008