Jaundice in Acute Cholecystitis

Frank jaundice in a patient with signs and symptoms of acute cholecystitis is uncommon. When present, it should raise suspicion of :

1. concomitant choledocholithiasis,
2. Mirizzi's syndrome (obstruction of the bile duct as a result of external compression of a stone in the gallbladder or cystic duct), or
3. another complication, such as gallbladder perforation.

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New England Journal of Medicine - Vol. 358, No. 26, June 26, 2008